Common Names: Duloxetine

What is it for?

  • Depression

  • Anxiety

  • chronic pain conditions (Fibromyalgia, CRPS, Lupus)

How is it administered? oral


  • Expensive and not accepted by all insurance companies as it is labeled as an antidepressant

  • Can cause weight gain

  • Can cause drowsiness and lethargy

  • Should not be taken when taking blood thinners or herbs that cause blood thinning, diuretics, migraine medication, NSAIDs, other antidepressant or anti-anxiety medication, or medicine for GERD/acid reflux

  • Difficult withdraws that can be dangerous and must be tapered off slowly, preferably with the guidance of a medical professional

  • Do not use if allergic to duloxetine

  • As with any mood related medication, it can actually worsen the conditions in some instances

  • Can cause serotonin syndrome (leaves you feeling helpless, lethargic, depressed, etc. after depletion of serotonin)

  • Low blood pressure issues

  • Can cause kidney and liver issues

Danger signs:

  • Worsening of anxiety or depression, including suicidal thoughts

  • Bleeding problems

  • Skin problems

  • Excessive weight gain

  • Dizziness and drowsiness, lethargy

Check with your doctor before taking any medication to make sure you do not have conditions or prescriptions that will interact badly with the medicine.


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